Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation.
نویسندگان
چکیده
منابع مشابه
Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation.
We studied the combined effects of Tat and general trans-activators, such as E1A and phorbol esters, on human immunodeficiency virus-1 (HIV-1) gene expression. Interaction between these two types of trans-activators may be involved in the transition from transcriptional quiesence during viral latency to active gene expression during productive infection. E1A cooperated with Tat to produce a fou...
متن کاملTranscriptional control: Tat cofactors and transcriptional elongation
HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.
متن کاملAdenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation.
UNLABELLED During infection by human adenovirus (HAdV), the proteins encoded by the early region 1A (E1A) gene bind and appropriate components of the cellular transcriptional machinery to activate the transcription of viral early genes. Previously, we identified roles for the human Bre1 (hBre1) and hPaf1 complexes in E1A-mediated transcriptional activation of HAdV early genes. Here we show that...
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متن کاملHIV-1 tat transcriptional activity is regulated by acetylation.
The human immunodeficiency virus (HIV) trans- activator protein, Tat, stimulates transcription from the viral long-terminal repeats (LTR) through an RNA hairpin element, trans-activation responsive region (TAR). We and others have shown that trans-activator protein (Tat)-associated histone acetyltransferases (TAHs), p300 and p300/CBP-associating factor (PCAF), assist functionally in the activat...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1990
ISSN: 0890-9369
DOI: 10.1101/gad.4.12b.2397